The present invention discloses compounds of Formula I: having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. The assessment is based upon measurement of binding of a bactericidal antibody to a capsular saccharide component in the vaccine. A second charge pump is charged during a time that overlaps with performing the first operation. At the time point when the temperature of the bonding material has reached a predetermined temperature, the applied pressure is increased from the comparatively low pressure to a comparatively high pressure.