The present invention provides an isolated, functionally-active protein that catalyzes cleavage of a gamma-secretase substrate. The phosphor coating method comprises the steps as follows: First a light emitting semiconductor wafer having a plurality of die units formed thereon is provided, and a photoresist is then formed on the light emitting semiconductor wafer to cover the die units. An aspect of an embodiment of the invention relates to performing data transformations to resolve potential consolidation conflict issues. The methods generally comprise providing an initiator to a cell comprising a detection target and a silencing target gene, wherein the detection target is different from the silencing target gene, wherein binding of the detection target to the initiator initiates formation of an inactivator double-stranded RNA. In certain embodiments, the invention comprises: a core comprising: a sulfonylurea or a pharmaceutically acceptable salt thereof; a pharmaceutically acceptable polymer; a membrane surrounding the core which is permeable to the sulfonylurea and gastrointestinal fluid, wherein said dosage form provides a mean time to maximum plasma concentration of said sulfonylurea. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.