The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator. In the present invention, the method for sending the PDCCH signals can solve the problem of conflict between the PDCCH and the primary synchronization signals in the DwPTS by generating a less delay and less impact on other channels. The system also comprises a customer system which is operably positioned in the first showroom for providing information to the customer about the one or more articles of commerce, and for facilitating an e-commerce transaction for the purchase of select ones of the one or more articles of commerce. The method also applies the gain value to the pixel in the image data. Methods of manufacture are described. The entropy results are plotted as a stacked bar chart.