It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Furthermore the protective insert includes two attachment mechanisms adjacent to the connective segment with each of the two attachment mechanisms adapted to removably attach one of the two optical fibers to the connective segment. The invention is to provide a method for screening and evaluating conformationally flexible ligands as potential lead compounds, because the method can be applied to search space for possible configurations of ligands in order to correctly dock into the active site of an enzyme.