An information storage system includes a transducer having a loop of ferromagnetic material with pole tips separated by an nonferromagnetic gap located adjacent to a medium such as a rigid disk. The method may be executable to receiving information associated with a first party, wherein the first party is connected to a second party by a social-network. The one-way valves have coaxial inner and outer members with reversed roles for fluid inflow and outflow tubing connections. The second set of operation tasks is performed in a second phase. Also provided are pharmaceutical compositions containing the positive allosteric modulators and methods of treating obesity or an obesity-related disorder such as type 2 diabetes, comprising administering an effective amount of the positive allosteric modulator.