Inhibition of replication of an infectious agent, gene expression of an infectious agent, or both, by administration of an oligonucleotide complementary to highly conserved regions of the infectious agent is described. The method includes identifying a sub-region of the substrate. The first power supply circuit is for supplying a first positive voltage to a first terminal of the current-driven device. The pressing device includes an interconnect assembly including a hydraulic hose having first and second couplings at both ends of the hydraulic hose for mating with the mating ends of the actuator and the work head, respectively. The spatially-separated polarization components of the reflected light are combined into output-light polarization components that are at least partially spatially coincident and out-coupled from the optical device. In one embodiment the results of the analysis are masked and the protocol key provided to a content addressable memory to identify the offset parameters.