The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epothilone. It includes a handle fixed to the pump casing cylinder, a shaft rod, a shaft rod handle and a piston that includes a flexible ball. The pseudo first power supply line and the pseudo second power supply line are clamped by an ESD clamping circuit such that the ESD protection circuit discharges voltage when an ESD event occurs, and does not interfere with the internal circuit when an over-voltage occurs. The integrated assembly further includes a latch bolt housing having a latch bolt slidably disposed therein and a spring for biasing the latch bolt towards the master frame.