A shaft revolution counter including one or more reed magnetic sensors interacting with one or more magnets attached to the shaft. The fiber optic bundle is arranged generally radially about an axis to carry radiative energy produced by a laser. The analog IF signal is converted to a digitally sampled IF signal having the first carrier located in a first Nyquist zone, the second carrier located in a second Nyquist zone, an image of the first carrier located in a third Nyquist zone, and an image of the second carrier located in the third Nyquist zone. The upwardly facing lip is configured to matingly engage the downwardly facing lip when the base member and the upper containment member are in an assembled position. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 andor a P2X23 receptor antagonists and methods of making the compounds.