Large-dimension MIMO and multipoint broadcasting in new generation of wireless networks create high demand for various types of pilots in transmission signals for channel estimation, data demodulation, synchronization, etc. There are also provided anticancer agents containing as active ingredient at least one of polyamine compounds represented by the following Formula or andor pharmaceutically acceptable salts thereof. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4.