Sickle cell disease is treated by administering a 5-lipoxygenase inhibitor. The chain includes a plurality of inner and outer chain links connected by pins. In some embodiments, the methods for making such ester-based lubricants utilize a biomass precursor such that the lubricant compositions generated by the methods and systems of the present invention can be properly deemed biolubricants. In one implementation, the amplifier includes a number of impedance matching network units, impedance transformer, and a power stage.