According to one embodiment of the present invention, a method and system for VLSI hardware design and synthesis is provided in which components provided by a heterogeneous modeling framework are interconnected, based on design specifications of a VLSI, to create a corresponding behavioral VLSI model. The attaching base portion has a generally L-shaped cross-section, and includes a bottom wall and an exterior side wall. Preferably, the object comprises breast tissue. A therapeutic or diagnostic agent may be delivered by the needle to the target region via the opening in the vessel wall.