The invention relates to modified restriction enzymes capable of being used for promoting homologous recombination in organisms, in particular plants, making it possible to either target gene integration or excise unwanted DNA sequences in the genome of said organisms. A level of thrust is dynamically identified using a drag on the aircraft needed to substantially maintain a speed of the aircraft in a turn to form an identified level of thrust during turning of the aircraft. 5 \u03a9\xb7cm or less and the p-type nitride semiconductor layer side is down-mounted so that light is emitted from the second main surface of the nitride semiconductor substrate at the opposite side from the first main surface. The methods provide process conditions which minimize the damage to the dielectric layer during resputtering. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.