A three-dimensional in vitro culture system comprising breast epithelial cells, endothelial cells and breast fibroblasts supports growth and functional differentiation of preneoplastic breast epithelial cells and endothelial cells and recapitulates estrogen induced in vivo effects on angiogenesis and proliferative potential of breast epithelial tissue. A system controller includes functionality for controlling a color balance of the red, green, and blue light. In various embodiments, information derived from the intended layouts of source documents is employed to construct specifications of the constituent parts. For example, based upon rules associated with each interested party, the central event processing system may forward information andor issue an alert or notification to an interested party to make the interested party aware of the medical event. The blade is secured within the slot by first and second clamp jaws defining opposing sides of the slot, each of the first and second clamp jaws includes a set of teeth extending towards each other at the front end of the head for retaining the blade therebetween. If the size of the write data is smaller than that of the memory management unit, the write data is cached by the high-performance non-volatile memory device; or if the size of the write data is not smaller, the write data is written to the low-performance device.