The present invention relates to a compound of formula, which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1. Through use of the client computer, a client requests the sever computer to appraise and register a card. This is done by use of a controller, which operates appropriate switches. Processor requirements for the complex hardware system are determined based on the optimal solution. In one embodiment the two components form one or more alternating layers.