A variation of the traditional game of bowling combining skill-based gaming methods and systems for maximizing interest and strategy within the traditional bowling scoring and playing environment to enable the bowler to compete for prizes. Magnetizable particles 35 and a group of magnetizable pins 40 are used for binding biomolecules 28 to the magnetizable particles 35 using a binding buffer 30b, and for transferring the magnetizable particles 35 forming a particle-biomolecule complex 36. Based on the state, an input panel is displayed that automatically changes its keyboard layout and key meanings based on what the user is likely to need, thereby increasing convenience andor usability of the input system.