The present invention provides compositions and methods based on genetic polymorphisms that are associated with autoinflammatory diseases such as psoriasis. In a further embodiment, the present invention relates to fabric care compositions wherein the amino acid sequence comprising one or more cellulose binding domains is linked to a softening protein. The polarization splitter devices are positioned to split the light inputs into respective refracted and reflected polarized components, and the electro-optical switch is operable by the application across it of a potential difference to recombine the polarized components and to couple them with the light output AT through the first outlet port. First, a messaging engine adapted to transmit airline data. After the third insulating spacer is removed, ion implantation is performed on the substrate on both sides of the gate structure using the second insulating spacer as a mask to form second doping regions serving as sourcedrain regions with the first doping regions.