Disclosed is medical equipment, the surface of which being at least partially provided with a coating which is provided by means of a sol-gel process. The pharmaceutical compositions may comprise one or more MDM2 inhibitors, and may further comprise one or more additional therapeutic agents. The majority of mutations clustered near two positions within the PI3K helical or kinase domains. The second electrode constitutes a part of the partition wall. An analyzer is provided for relating a spectral response of the gas of interest to a property of interest, such as an energy content of the gas of interest.