A computer apparatus is associated with a graphical display presenting at least one GUI-component adapted to be manipulated based on user-generated commands. The cathodic element comprises an inclined cathodic wall in the electrolyte above the generally horizontal cell bottom. The supervisory control unit can be configured to execute a central optimization algorithm that computes variables from across multiple powertrain subsystems, and then outputs a number of globally approximated command values to each associated subsystem control unit. In various embodiments, an endoscopic suturing device is inserted through a patient’s mouth, down through the esophagus, and positioned in the region of the defect, e.