This invention is a distributed database system, which comprises a plurality of database domains which include one or more databases, and each of database domains is administered by a topology administration server. The combination therapy of the present invention shows enhanced anti-cancerous therapeutic effects compared to the effect of each of the components administered alone. If some Nodes are mobile the ability to route to and from the mobile Node persists. Once relevance is determined, the method includes applying relevant email addresses to a user’s store of relevant addresses. With this, the vacant capacity for the amount of data desired to obtain by the mobile terminal can be secured in the mobile terminal.