A reinforced flexible hose includes at least one inner tubular layer of plastic or rubber, a knitted reinforcement, which has substantially, parallel rows and lines of substantially parallel stitches, with respective stitch counts per unit length of the hose ; and an outer layer which is superimposed on the reinforcement layer to protect it. The tool can be conveniently used to first remove a material from a can, bucket or other material container and then used to spread the material evenly on a surface or substrate. The holding and releasing unit is connected to the tube such that liquid can pass from the tube into the holding and releasing unit bore. The promoter regulates expression of a therapeutic gene. The calibration device includes a first console port positioned at or near the farm vehicle and a second console port at or near the metering system, each operative to receive at least one a calibration console for calibrating the rate of product delivery and adjust the metering system accordingly. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited.