A solid support for maintaining a uniform spot shape while improving the capacity for immobilization of nucleic acids upon spotting of nucleic acids onto a solid support is provided. This invention teaches that ultrasound applied to the shell of a seed will develop micro-punctures which enable the faster absorption of water and other liquid nutrients into the seed structure. A photoresist layer is coated overlying the layer to be patterned. The invention is particularly useful for eliciting desired biological responses in human and animal medicine, and in certain industrial applications. The ALAB includes entries that are associated with data values that a leading thread has retrieved.