Variable liquid crystal devices for controlling the propagation of light through a liquid crystal layer use a frequency dependent material to dynamically reconfigure effective electrode structures in the device. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. 961; MxDyTz, wherein x is about 0. The coefficients are preferable derived from a time series signal X, t=1, 2,. 5 MPa<E<300 MPa at 160-200\xb0 C. In one embodiment, ranolazine is administered as an oral dose.