Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs and drugs requiring storage in aqueous or other water-miscible pharmaceutically unacceptable vehicles for stability are provided. In one exemplary embodiment, a portable computing device in the form of an animal, such as, for example, a bear, with a manipulatable user interface, is used to log onto and off of various computers. The temperature data detected by the temperature sensor is corrected based on the correction data. A perimeter portion of the front substrate extends beyond a corresponding perimeter portion of the rear substrate to establish a user input region that is outboard of the electro-optic active region. Specific control of microbial growth and activity in this process results in prevention of nutrient loss in transit and allows better targeting of microbial activity to the desired subsurface location.