A method for creating and maintaining a search knowledge-based system with respect to company, product and service resources within an industry, using a knowledge base data content structure having categories, rule sets, search parameters, data sources, and data content input from the plurality of data sources. A kit useful for performing a fluorimetric screening of drug binding to serum proteins is also disclosed. In this boiling cooler, the refrigerant vapor can be cooled by cooling water having a thermal conductivity larger than that of air. The system may be used to distribute and manage optimizations for an application, which may be deployed in interpreted or runtime scenarios or in pre-execution or compiled scenarios.