The present invention relates to a device for determining a characteristic point in the cardiac cycle that comprises means for calculating the curve of the blood flow rate D in the aorta from the curve of the arterial blood pressure signal P and determining from the curve of the blood flow rate D in each cardiac cycle the time at which an the incisura point lies. At each of said provider sites one-time cryptographic credentials associated to said site identifying feature are generated each time a user tries to verify whether the site fulfils predetermined conditions and said verification server authenticates at said each time said site identifying feature by processing said one-time cryptographic credentials. Methods for using the RNA-modulating agents, miRNA inhibitors and diagnostic agents are also provided.