A device comprises a multi-layered thin film having excellent adhesion due to the method of fabricating the same. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. Through use of a user interface, the strategy can be represented as a graphical decision tree, with terminal nodes representing services or actions. The channel region has a portion located along a sidewall of a semiconductor structure having a surface orientation of.