The ligand polypeptides of the present invention have activity to regulate CRH secretion, and thus are useful as CRH secretion regulators for the relief, prevention or treatment of various diseases related to CRH secretion, such as hypoaldosteronism, hypocortisolemia, secondary and chronic adrenocorticism, Addison’s disease, adrenal dysfunction, and obesity, and also as analgesics. The timer, having a delay configured to track inversely with temperature of the memory device, includes a reference signal configured to increase in voltage, as the temperature of the memory device increases. The housing defines an internal cavity in communication with an opening of the housing.