The subject invention relates to electronic buying and selling systems and methods. Antibody fusion proteins of the invention include a hybrid antibody moiety containing sequences from more than one type of antibody andor mutant antibody sequences. The plurality of light emitting diode chips are mounted in the cavity. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.