The present disclosure provides methods of reducing levels of lactate in a fluid or tissue in an individual. One such compiler generates machine code corresponding to a set of elements including a general purpose element and a special purpose element. 0 gm100 ml, phenol and 95% ethanol in the ratio ranging between 1:4 to 2:1, and phenol and distilled water in the ratio ranging between 1:14 to 1:25. Each bone fastener assembly may include a bone fastener and a collar.