This invention relates to novel compounds of formula :and derivatives thereof useful for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3\u2032 OH kinase family, suitably, PI3K\u03b1, PI3K\u03b4, PI3K\u03b2, andor PI3K\u03b3. The one dispenser 20 supplies the resin directing to an upper side corner on a liquid crystal cell 1, while the other dispenser 40 directing to a lower side corner thereon. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer’s disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis and Crohn’s disease. During a second calibration phase, the filter frequency is adjusted to a second frequency approximately equal to a frequency of the AC signal, and a second signal is measured. Removal of the elastomeric material provides a plurality of cavities, which are filled with an epoxy including nanoparticles. Similarly disclosed is a novel method of conditioning soccer players to improve their ability to score goals.