A spinal three-dimensional orthopedic equipment includes a frame for fixing an operation means and a drive device, a front board member and it’s drive device fixed on the frame, a back board member and a middle board member as well as their drive devices fixed on the frame, and a head holding means fixed on the middle board member for holding the patient’s head. The ADPLL may also be used for direct frequency modulation. Use of the novel constructs of the invention facilitates transformation of a wider range of plant species and enables ubiquitous expression of a transforming DNA in plastids of multicellular plants. The outlet is in gas communication with the inlet.