There are provided compositions which include a retinoid and preferably retinol; an acid; and an acid neutralizing effective amount of ammonium hydroxide. The image sensor includes a plurality of light-receiving portions for converting a signal corresponding to the light of an object to an electrical signal, and a pixel array area having a plurality of micro lenses formed above the light receiving portions and respectively corresponding to the light-receiving portions to focus the light. A reference voltage VREF is first applied to the capacitor elements, then a first sample signal VS1 from the image sensor pixel is applied to the first capacitor element producing a charge that is transferred to the second capacitor element. Each of the end members is joined at one end to one of the post receiving members and is joined at another end to another of the post receiving members. The detecting engine is employed for detecting abnormalities within at least one of the medical images comprising the examination bundle. In one aspect a load-bearing orthopedic implant includes a reinforcing polymeric structure including a continuous piece having an internal interconnected porous network.