Silicon fins are formed in a bulk silicon substrate and thereafter trench isolation regions are formed between each silicon fin. Replication may be triggered, scheduled, performed in response to an unload, or performed during backup processes. The present invention further provides therapeutic compositions enabling dose-dependent or dose-specific administration of agents useful in the treatment and prophylaxis of age-related macular degeneration or related retinal degenerative conditions. Each pin is held in the puck by an interference fit making the pins easy to replace. An adjustable voltage supply may be used in any desired context, not just memories. The ridge assembly stands proud of the upper margin of the respective adjacent slope sheets.