A method and apparatus for manufacturing small batches of solid paint is disclosed, which method includes a first step of providing a component of the solid paint as a liquid in a heated mixing container that has a base and sides and includes a stirrer for stirring the contents of the container. The navigation system includes a navigation processor configured to obtain a destination location, and to generate a proposed route to the destination location. The distal region has a distal stiffness and a first spiral configured to retain the distal region in the internal jugular vein. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles. Other embodiments are also described and claimed. Methods of diagnosing, characterizing and treating M.