A coupling structure of a heat transfer plate and a gasket for use in a plate type heat exchanger. An in-line processing system can be utilized based on a continuous indexing of microarray slides or substrates through a series of processes where different functions or processes are performed at different positions on a conveyor. Data associated with a channel of the palette is filtered, and stored, for example, together with a pixel buffer of the image to form a filtered image. The method includes generating data for registering the off-line encryption device; encrypting the data with one or more cryptographic keys to form encrypted data; forwarding the encrypted data to the off-line encryption device; and retrieving the data from the encrypted data, wherein the off-line encryption device begins to encrypt clear content only after the data is retrieved. Since the openings that are formed in the resist are provided in advance with shapes that compensate for the deformation that occurs when the openings shrink, these openings attain the proper shape after undergoing shrinking and deformation.