A biopsy system includes a biopsy device operable for taking one or more biopsy samples from a patient and a marker delivery device. Relative movement between the gas permeable partition and the surrounding material forms sub-micron sized bubbles in the liquid, slurry, or sludge. The arrangement comprises cards adapted to storing relevant values of said crankshaft angle as a function of at least one operation-related parameter and means for estimating values of the operation-related parameter during operation of the combustion engine. Furthermore, a device domain controls access to a disk drive so that data corruption can be prevented. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of ATOH1.