Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. The device includes a first component comprising a first adhesive-backed anchoring member and one or more first connecting members extending from one edge thereof in a first direction. The pouch contains a removable temperature transference source therewithin. As long as one clock is active, the START signal of the other clock will not have any effect. Localized light patches are determined based on a FLD model and a designated patch size is accordingly determined. Formulations which include various embodiments of the mesogen containing compounds and their use in articles of manufacture and ophthalmic devices are also disclosed.