Compounds of formula Iin free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Once the particles are positioned, fixation is accomplished by pumping an electrolyte solution or pH adjusted solution into the sample cell. A first tuned circuit is provided for being electrically coupled to an external power source and for, in isolation, providing a first periodically varying electrical signal having a first frequency. 9% by weight of Ag and from about 0. The entire length of the at least one volute from a turbocharger inlet is axially inclined relative to the reference plane so the fluid flows in both a radial and axial direction.