The apparatus comprises an ultrasonic vibration generator and a lens affixed thereto adapted to focus the ultrasonic vibration at a predetermined zone. The data stream has an associated eye pattern that contains a data value for each of a plurality of threshold points defined by a plurality of amplitude rows and a plurality of phase columns. For example, a tissue ablation device having an actuator, such as a trigger mechanism, coupled to a power source and an electrode is discussed. The invention further relates to screening methods for identifying agonists and antagonists of TR11, TR11SV1, and TR11SV2 receptor activity. A computer-readable medium including instructions stored thereon, that when executed by a processor may cause the processor to manage a meal database. Moreover, the pulse amplifier 2 comprises a normal dispersion medium and an amplification medium that are multistage-connected alternately, for changing the input pulse 10 to a light pulse having a linear chirp and outputting the light pulse.