A full digital phase locked loop is comprised of a first counter for continuously counting pulses of a first clock pulse stream to produce a varying count number. The torque generator generates a torque that counters a reactive torque when a drill bit of the bottom-hole assembly is driven. 1 and P10155, herein identified as adhesion molecules and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease. A rod-shaped rigid metal core wire 14a having a relatively larger diameter is connected in a unified form to the small diameter metal core wire 14 and a heat resisting coating layer 16a is also applied onto the core wire 14a. when the first output pin transitions to a new state. The isopreniod compound may be farnesol, which is particularly effective against the pathogenic yeast Candida albicans.