A method and system for orthodontic treatment planning, evaluation and quality measurement is provided comprising a workstation having computing platform, a graphical user interface, a processor and a computer storage medium containing digitized records pertaining to a patient. A pivoting center around which the movable member is pivoted with respect to the fixed member is a position of the first ball when the movable member is moved along the first long groove and the second long groove. The spraying device is arranged to project the droplets into a determinable droplet trajectory and the at least one energy source is arranged for providing energy focused substantially on the droplet trajectory. Also described are improved biotinylation reagents. One example of such self-controlled one-way valves is a check valve. The probe has a main body that guides light in an axial direction by total reflection by a side wall, and that is located behind the plasma introducing portion.