The present invention is a composition for providing localized delivery of a therapeutic agent to a subject. In the method non-editable computer readable instructions for a presentation at a remote location are received from a central data storage via a data network. The input device also includes a plurality of protrusions extending from the central body. Next, the second intermediate image is up-sampled along a second direction to generate a third intermediate image. The second surface roughness is quantitatively less than the first surface roughness, and substantially no material is removed from the article surface in the step of second processing.