Some embodiments provide a computer readable medium storing a media editing application for creating multimedia presentations. The first therapeutic substance is delivered to the patient at a known flow rate, a bridge duration equal to the known volume divided by the known flow rate is calculated; and the flow rate is controlled following introduction of a second therapeutic substance into the reservoir. In this structure, a built-in electric motor section can be appropriately cooled over a wider area by the sucked gas, so that a rise in temperature of the motor section can be properly suppressed. This makes the present voice coil have more strength and longer lifetime, and helps to design a thinner loudspeaker and increases the heat dissipation efficiency of the voice coil. These compounds inhibit tubulin polymerization andor target vasculature and are useful for treating proliferative disorders, such as cancer.