A pulse stimulation system configured for implantation into a patient’s body comprises a pulse stimulator, a conductive stimulation lead having a proximal end electrically coupled to the pulse simulator and having a distal end, and an electrode assembly coupled to the distal end of the stimulation lead. An alignment process is performed on a surface of the first substrate and a surface of the second substrate respectively. The detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome. A single mechanical fastener is used at each joint to connect the frame sides, arms and shoe bars together.