The present invention relates to novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy and antibody-directed enzyme-prodrug therapy, in conjunction with nitroreductase enzymes. The disclosed methods and systems utilize various data inputs, including affirmative user inputs, non-affirmative user characteristics, environmental data andor temporal data to customize channel programming for a particular user or group of users. The piston is movable between a first position for lifting and pulleys and guides are mounted to the pilings and the cradle. A cursor control device is mounted on the pen shaft beside the pen point. According to the method of providing a search service, a web page that is searched by a specified keyword is accessed, at least one keyword is extracted from text included in the web page being accessed, and the at least one extracted keyword is displayed. The deformable seal member includes one or more fuel passages through which fuel in one or more fuel circuits flows with the seal member sealingly separating the first and second fuel circuits and preventing external fuel leakage from the nozzle tip.