A driving circuit for an input display is provided. The photodetector includes a sufficient thickness of a high density material to create a sufficient number of photoelectrons from incident MV radiation, so that the photoelectrons can be received by the conversion layer and converted to a sufficient of recharge carriers for detection by the detector array. The compounds of the present invention are also useful in treating osteoporosis andor frailty when used in combination with: a bisphosphonate compound such as alendronate; estrogen, premarin, and optionally progesterone; an estrogen agonist or antagonist; or calcitonin, and pharmaceutical compositions useful therefor. The apparatus may also include a sensor adapted to detect the presence of the perpetrator, for example, an optical or mechanical sensor.