A method and computer program product for optimization of large scale resource scheduling problems. A tissue securement device having securement arms is positioned through portals formed in opposing tissue walls of an organ. In addition, the controller is capable of intelligently communicating with the input and output devices of the system, and particularly with each individually interfaced appliance, such that the controller can adaptively control the system through the use of stored historical data. The base wall including a mounting structure for mounting the base wall to a first structure. It also relates to electronic devices in which the active layer includes such a deuterated compound.