Disclosed are compounds of formulae, ,, ,, ,, and, wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction andor natural killer induction. The invention encompasses a device for detecting an occlusion including a sensor for sensing a fluid flow parameter andor an operational parameter of the device and an evaluation unit for processing the output of the sensor. A pivoting movement of the release lever linearly moves the release rack, which engages and rotates the gear in a first direction. A map function receives an input event from the event stream and publishes one or more events to the event stream.