An apparatus and method for testing a dielectric layer. Methods are provided for enhancing the growth of collateral arteries andor other arteries from preexisting arteriolar connections comprising contacting tissue or cells with a monocyte chemotactic protein or a nudeic acid molecule encoding said MCP. The substrate has a sensing region and a periphery region. This avoids an undesired feed forward effect at the beginning of the. A wrapper can be downloaded to manage Alert Messages, a mailbox, and to update on board applications. Upon detecting a discrepancy between the prediction and the actual outcome, the controller may provide a continuation signal configured to indicate that additional training may be utilized.