Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions. The composition has many advantages including improved focal latitude, improved resolution, minimized line width variation or shape degradation even on long-term PED, minimized defect left after coating, development and stripping, and improved pattern profile after development and is suited for microfabrication by any lithography, especially deep UV lithography. The present invention can be used for controlling the maximum voltage of a load and for changing motor speed. Methods have also been discovered to genetically alter pPS cells by introducing the cells with a viral vector or DNAlipid complex. The micro-roughness structure functions to improve the light extraction of the electromagnetic radiation and to direct the electromagnetic radiation outward from the lens. The tip of the probe has a retraction blade having a pair of suction ports lying above a pair of ports in the distal end surface of the probe.